The DAC modification significantly extends its half-life, allowing for prolonged activity and making it ideal for studies on muscle growth, recovery, anti-aging, and fat metabolism
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For example, when intracellular cholesterol levels are lowered, SREBF2 is activated and translocates to the nucleus where it binds to the sterol regulatory element (SRE) within the CYP51A1 promoter to enhance its transcription
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Pathophysiological and pharmacological implications