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GLP-1 analogues are powerful metabolic tools, but they demand strict medical oversight

Interestingly, within these neuronal clusters, GIPR antagonism and GLP-1R agonism are separated from GIPR agonism in that they both similarly downregulate gene programmes indicative of neuronal plasticity and synapse formation

When GLP-1 binds to its receptors in neural tissue, it triggers intracellular signalling cascades that influence neuronal activity, synaptic plasticity, and cellular survival mechanisms

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