Afkarian M, Sachs MC, Kestenbaum B, et al
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Semaglutide is primarily recognized for its metabolic benefits, including regulating blood glucose levels, promoting weight loss, and enhancing lipid profiles
JAMA Netw Open 7(8):e2423385 Zhou J, Huang W, Xie Y, Shen H, Liu M, Wu X (2025) Risk of ophthalmic adverse drug reactions in patients prescribed glucagon-like peptide 1 receptor agonists: a pharmacovigilance study based on the FDA adverse event reporting system database
The challenge arises when caloric restriction is too severe or protein intake too lowconditions which potentially exaggerate SHBG production and blunt these benefits