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For example, A 2023 study in the New England Journal of Medicine found that semaglutide reduced the risk of death from heart disease and nonfatal heart attacks or strokes by about 20 percent for people who were obese or overweight

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The REWIND study evaluated the cardiovascular safety of dulaglutide (1.5 mg) in comparison to placebo ( Exenatide The EXSCEL (Exenatide Study of Cardiovascular Event Lowering) trial evaluated the CV safety of exenatide (2 mg weekly)