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335,336 The expression of iNOS is primarily activated by the NF-B pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS

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Consistent with the above findings, PD transgenic mice display an accumulation of enteric -syn, alterations in the integrity and permeability of the intestinal barrier and a high degree of intestinal inflammation in the presymptomatic phases of the disease [85, 86]

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