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This cross-talk suggests that therapies tested in sepsis (like IL-1 blockers, metabolic cofactor supplementation) could be repurposed in high-risk surgical patients

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These nanoscale, bilayer-bound vesicles carry diverse bioactive cargo and have been shown to modulate gut microbiota, enhance epithelial barrier integrity, regulate immune signaling, and support metabolic homeostasis

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[37] [38] Biochemistry [edit] Biosynthesis [edit] The biosynthesis of melatonin in animals involves a sequence of enzymatic reactions starting with L-tryptophan, which can be synthesized through the shikimate pathway from chorismate, found in plants, or obtained from protein catabolism

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