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Quality assessment and critical appraisal for the systematic review of the included studies The methodological quality of the included studies was evaluated independently by two reviewers using the Study Quality Assessment Tools developed by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH), tailored to the design of each included study

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This finding is consistent with a previous report demonstrating that BAT-specific deletion of GSNOR impairs cold-induced UCP1-dependent thermogenesis 36