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Meta-analysis of results reported from SURPASS-1 to -5 clinical trials regarding achievement of HbA 1c targets
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Murray-Smith, S.Q., Scott, B.J., Barton, D.P
Loureiro D, Tout I, Narguet S, Bed CM, Roinard M, Sleiman A, Boyer N, Pons-Kerjean N, Castelnau C, Giuly N, Tonui D, Soumelis V, El Benna J, Soussan P, Moreau R, Paradis V, Mansouri A, Asselah T
If steps 1 to 3 don't resolve symptoms after 3 to 4 weeks, talk to your provider about: Whether a dose pause or reduction is appropriate Whether other medications are contributing (especially in patients also on antidepressants or hormone therapies, where sweating effects can compound) Lab work to rule out other causes (thyroid, infection, hormonal changes) Whether the symptoms are severe enough to warrant a medication change Most patients don't need step 4
Ozempic initially had a stable but relatively small user base, comprised primarily patients with T2D who could not take or werent responding to the existing first line treatment metformin
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