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Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

In the amyloidogenic pathway, APP via and secretases is converted to the neurotoxic A which promote the formation of amyloid plaque

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimers Disease

doi:10.1016/j.ymben.2003.09.001

Fontana L, Partridge L, Longo VD

In the field of procedural cell death, ferroptosis is a regulated form of cell death that depends on iron ions and lipid peroxidation, which is considered to be related to the development of a variety of diseases, including neurodegenerative diseases, cancer, acute kidney injury (AKI) and chronic kidney disease (Jiang et al., 2021)