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Unlike traditional medications such as disulfiram, naltrexone, and buprenorphine, which primarily target neurotransmitter pathways directly associated with addiction, GLP-1RAs modulate reward mechanisms indirectly through metabolic and neuroendocrine pathways

Particularly, participants not receiving sulfonylureas as baseline therapy profited from tirzepatide regarding hypoglycemic episodes (tirzepatide 1%3% vs

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"The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus"

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Beyond glycaemic control, GLP-1 medications have a significant effect on appetite regulation