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Due to significant metabolic alterations in tumor cells, oncologists have long expected to treat tumors by inhibiting upregulated metabolic pathways, but the actual effects have been suboptimal

However, whether ferroptosis is involved in melanocyte destruction is unknown (100, 101)

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The landmark study by Juhlin and Olsson (1997) suggested that supplementation with vitamin B12 and folic acid combined with sun exposure could promote repigmentation