High-dose oral therapy (10002000 micrograms daily) can effectively treat deficiency even in those with impaired intrinsic factor-mediated absorption, relying on passive diffusion
For this reason, we recommend to inject daily, especially in the presence of neurological symptoms
For example, peptides help orchestrate hormone activity, immune defense, tissue repair and growth, control of inflammation, and digestion
GI symptoms that persisted through titration often resolve or become so mild they are barely noticeable
WHO: Advocates 1,000 mcg/day oral or weekly injections in deficient regions (e.g., Africa), reducing anemia by 15-20% in 2025 trials
Miras AD, le Roux CW