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Beck RW, Raghinaru D, Calhoun P, Bergenstal RM (2024) A Comparison of continuous glucose monitoring-measured time-in-range 70180 mg/dL versus Time-in-Tight-Range 70140 mg/dL

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Spaniolas said some patients never have used GLP-1s because of the price

Clinical studies have shown Tirzepatide's remarkable ability to facilitate significant weight loss, improve blood sugar levels, and boost overall metabolic health, making it a promising option for individuals seeking comprehensive weight management

Patients will often start to notice the effects that Ozempic has on their appetite within the first week or two of treatment, with the initial weight loss benefits often being noticed a month or two following the start of treatment

Potential benefits being investigated include: Cognitive performance : Some small-scale human studies have shown mixed results on cognitive tasks among participants receiving GLP-1 receptor agonists, with no consistent pattern of improvement established in randomised trials to date Cognitive decline : Observational data from diabetes cohorts suggest that patients prescribed GLP-1 agents may experience different rates of cognitive deterioration compared to those on other diabetes medications, though causality cannot be established Dementia risk : Population-based studies have indicated a possible association between GLP-1 receptor agonist use and dementia diagnoses, though these findings require confirmation in prospective trials Neuroimaging markers : Early research is examining potential effects on brain structure and function, but definitive evidence of preservation of brain volume has not been established Important limitations and considerations: Limited human trial data : Most evidence comes from animal models or observational studies