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2015;7:a006080 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al

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This review concluded that intakes up to 2 g/day are safe for chronic supplementation. An International Olympic Committee (IOC) statement on dietary supplements for high-performance athletes stated that No negative health effects are noted with long-term use of creatine

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Dogs produce L-carnitine using lysine and methionine found in the liver, brain, and kidneys