Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT
This is critical because once you puncture the rubber stopper and introduce solvent, the vial will be accessed multiple times over several weeks
This approach is clinically defensible and reduces barriers to starting treatment, but it means that some patients may begin treatment without the metabolic baseline data that could improve their care
Benzyl alcohol, the preservative in bacteriostatic water, is contraindicated in neonates and premature infants due to the risk of gasping syndrome, as noted in BNF and MHRA guidance
The agency also flagged dosing errorsparticularly in multi-dose vialsand called for stronger oversight
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