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In a small clinical trial in patients with breast cancer taking tamoxifen 20-30 mg daily, adding curcumin 1200 mg plus piperine 10 mg three times daily reduces the 24-hour area under the curve of tamoxifen and the active metabolite endoxifen by 12.8% and 12.4%, respectively, as well as the maximum concentrations of tamoxifen, when compared with tamoxifen alone

Furthermore, BPC-157 is a potent stimulator of F-actin production in fibroblasts, which was revealed by experiments using FITC-phalloidin staining, and analysis by Western blotting showed that BPC-157 enhances phosphorylation of paxillin and FAK proteins - critical proteins in the cell migration pathway

Endocrine, 87(1), 159-169

In line with this study, in a double-blind, placebo-controlled RCT enrolling PCOS women with BMI 25 kg/m 2 , Nylander et al