Biological Chemistry, 390(3), 191214
Chioma Uzoigwe, Yuanjie Liang, Yurek Paprocki and Sarah Whitmire all critically analyzed and interpreted the data included in the manuscript, as well as drafting and revising the manuscript
Hormone Replacement Therapy Hormone replacement therapy (HRT), including testosterone replacement therapy (TRT) for men and hormone therapy for women, requires comprehensive medical evaluation and ongoing monitoring by qualified healthcare providers
This does not mean the switch has failed
It also mimics a second hormone called glucose-dependent insulinotropic polypeptide (GIP)
Bottom Line Here's what the data tells us: GI side effects dominate: nausea, diarrhea, vomiting, constipation Higher efficacy = slightly higher side effects at maximum doses Glucagon adds benefits: liver fat reduction, increased energy expenditure Slow escalation helps: 20+ week titration minimizes symptoms Still investigational: Phase 3 trials ongoing, FDA decision expected 2025-2026 Sources Retatrutide Phase 2 Trial (Jastreboff et al., NEJM 2023) TRIUMPH Phase 3 Trial (ClinicalTrials.gov) ClinicalTrials.gov Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice