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Long-term use of GLP-1 receptor agonists like Ozempic has been associated with an increased risk of vitamin B12 deficiency
Neelakantan et al., NNMT inhibition reverses diet-induced obesity in mice (2018) Babula et al., NNMT inhibition mitigates obesity-related metabolic dysfunction: fat mass, glucose tolerance, hepatic steatosis, pharmacokinetics and off-target screen (Diabetes Obes Metab, 2024) Dimet-Wiley et al., NNMT inhibition mimics and boosts exercise-mediated muscle improvements in aged mice (Sci Rep, 2024) NNMT inhibition and muscle function in aged mice (2019) Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice (2022): the diet-switch combination study Awosemo et al., rat pharmacokinetics of 5-amino-1MQ (2021) NNMT in metabolism and disease: review Sigma-Aldrich: 5-Amino-1MQ iodide product data (CAS 42464-96-0) FDA: bulk drug substances used in compounding under section 503A Disclaimer: Informational and research purposes only, not medical advice
It serves as a vital reagent for scientific investigations requiring precise modulation of cellular enzymatic activity without off-target binding
The deficiency can arise due to improper diet or the inability to absorb the vitamin through natural means
Under the Human Medicines Regulations 2012, the supply and advertising of unlicensed medicines for human use is restricted in the UK
Most vitamin B-12 we consume comes from animal meat
