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However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies

Future Perspectives The scientific studies on seleno-GPxs have so far led to the understanding that the physiological role of seleno-GPxs is not only limited to detoxification of peroxides, but also involves regulating signaling pathways (such as chromatin remodulating, NF-B activation, insulin signaling, mitochondrial integrity, and ferroptosis, among others) [1, 8,9,10]

If symptoms persist, reducing the dosage usually helps

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doi: 10.1016/j.colsurfb.2020.111284 89 MuYWuGSuCDongYZhangKLiJet al

Challenges 12