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In this context, recipient membranes are not passive targets

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GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis

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These changes reduce its binding affinity to IGF-binding proteins (IGFBPs), allowing for a longer half-life (up to 2030 hours) and increased bioavailability in plasma

Second, no or only mild heterogeneity was found in any of the meta-analyses conducted in the present study