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Acetaminophen hepatotoxicity: Paradigm for understanding mechanisms of drug-induced liver injury

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doi: 10.1371/journal.pone.0069010, 35 EgeciogluE.SteenslandP.FredrikssonI.FeltmannK.EngelJ

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Giorgino, F., Vora, J., Fenici, P

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The mechanism involves ginger compounds interacting with serotonin receptors in the GI tract, promoting coordinated muscular contractions

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Long-Term Risks Concerns have been raised regarding potential associations with pancreatitis, gallbladder disease, and thyroid C-cell tumors , although evidence remains inconclusive and risk appears low

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Treatment with metformin and DPP-4 inhibitors was associated with a reduced risk of fractures overall [129]

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