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Second-Line Pharmacological Treatments Antidepressants Targeting Persistent Abdominal Pain Antidepressants are beneficial for IBS patients potentially due to their central effects, but most importantly due to their peripheral effects targeting underlying mechanisms, such as visceral hypersensitivity, pain perception, and motility (Ford et al., 2019)
Int J Mol Sci (2015) 16(9):20195211
This interaction influences the assembly and disassembly of microtubules and actin filaments, which in turn affects cell shape, movement, and migration (Wang and Li, 2007)
That is a substantial monotherapy effect for an appetite-axis-only agent, and it established cagrilintide as a credible weight-management candidate on its own
GLP-1 (glucagon-like peptide-1) is a hormone that plays roles in appetite suppression and glucose regulation
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