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For observational studies (cohort and case-control), the NewcastleOttawa Scale (NOS) ( Risk of bias was interpreted as follows: i) Low risk: All criteria met or no more than one rated as unclear

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Quality assurance procedures include High-Performance Liquid Chromatography (HPLC) purity analysis, molecular identity confirmation, peptide sequence verification, copper complex validation, molecular weight characterization, and rigorous batch-specific quality control testing