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When performing an intention-to-treat analysis, the HR for MOF was found to be 0.89 [0.781.02] with GLP-1 RAs compared to DPP-4is, although this became significant in the fully adjusted model (HR 0.85 [0.74 0.98])

2.51% reduction in skin melanin after 2 weeks

Melanotan 2 is less selective and interacts with multiple melanocortin receptors, which may lead to broader biological effects

Lets look a bit deeper into the differences between 503A vs 503B

Similarly, studies on DPP-4is have found neutral effects on fracture risk (2325)

It won't produce the obvious appetite suppression of Reta or the noticeable energy shift of MOTS-C