According to Yucca Health's safety information pages, the most common side effects include: Gastrointestinal Effects: Nausea (most common, especially early on) Diarrhea Constipation Vomiting Indigestion and abdominal discomfort Feeling full quickly after eating Other Common Effects: Headache Fatigue Dizziness Managing Side Effects: Most patients find that nausea and gastrointestinal symptoms improve as the body adjusts to the medication
For some patients, a step-down option to a lower-burden oral GLP-1 is useful, either short-term to bridge the transition, or as a lighter form of long-term support if and when it is clinically appropriate
The simplest way to think about it: Wegovy and Zepbound work by targeting specific receptors in your bodyWegovy focuses on GLP-1, while Zepbound activates both GLP-1 and GIP receptors
Mild Flu-Like Symptoms: Some individuals may experience fatigue, headache, or nausea, particularly when first starting treatment
If you're currently on Saxenda and considering the switch to semaglutide a common scenario now that compounded semaglutide is available at a fraction of brand costs the transition requires careful planning with your medical provider
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