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Their blood sugar effects are substantial: Semaglutide: Reduces A1c by 1.5-1.8% from baseline (Ozempic trials) Tirzepatide: Reduces A1c by 2.0-2.3% from baseline (SURPASS trials)

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How Ozempic Causes NAION

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It's weird to think that it was not that long ago that people died of it and now we rely on an injection every couple of months

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If you accidentally create foam, let the vial sit undisturbed in the refrigerator for 10 minutes, then inspect

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Gq/11 interacts with PLC, which may split a fat-like molecule, phosphatidylinositol 4,5-bisphosphate (PIP2), into two messaging molecules: IP3 (Inositol trisphosphate) and DAG (Diacylglycerol)

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