(2024) 11:e2305563
Environmental epigenetics in metal exposure
Upregulated humoral factors, such as Midkine, further promote tubulointerstitial injury by accelerating local NETosis and subsequent tubular cell death (220)
It is generally believed that methylation modifications of H3K4, H3K36, and H3K79 promote the expression of genes, while methylation modifications of H3K9, H3K27, and H4K20 inhibit the expression of related genes (Wu et al., 2007
Dias GF, Bonan NB, Steiner TM, Tozoni SS, Rodrigues S, Nakao LS, et al
Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family