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Studies in mice suggest that GIP may potentiate the GLP-1-induced reduction of food intake and body weight by enhancing POMC expression and neuronal activation within distinct neuron populations in the hypothalamus (149)

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(See Hothas Step 1 ( [8] ).) Human Review Procedures : For each AI touchpoint, establish documented procedures requiring that all AI outputs are reviewed, modified if necessary, and formally approved by qualified personnel before they enter the controlled documentation or decision record

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