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Linus Pauling Institute Oregon State University Updated in July 2018 by: Barbara Delage, Ph.D
The most common areas treated are the upper face: forehead lines (horizontal lines from raising the brows), frown lines (vertical lines between the brows in the glabella region), and crow's feet (lines radiating from the outer corners of the eyes)
The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period
Nature [^7]: Miller CA, Golden KD, Mallett AK, et al
Not intended for human use, diagnosis or treatment
thus, the spectrum of GSS mutations and the genotypephenotype association remain unclear
