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Given the uncertainty in the incidence in a highly selected group of CVS patients, the non-inferiority margin was defined based on a proportion (50%) of the Control group rate rather than on a fixed incidence target

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The new TRIUMPH-1 results solidify these earlier, smaller-scale observations by demonstrating that retatrutides therapeutic trajectory can actually surpass those benchmarks over extended timelines, reaching a surgical-level 28.3% average weight loss at 80 weeks and up to 30.3% at 104 weeks

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doi: 10.1111/dom.14640 73 SammsRJChristeMECollinsKAPirroVDrozBAHollandAKet al