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GLP-1 drugs promote satiety themselves (this seems to be their mechanism of action), so the food consumed need not promote satiety as much

However, toxins such as environmental pollutants, drugs, and chemicals in food can impair the methylation pathway by interfering with the enzymes involved in the process and depleting the body's stores of crucial components like SAMe and methionine

10.1371/journal.pone.0098135 185 YoshidaJ.IshikawaT.EndoY.MatsumuraS.OtaT.MizushimaK.et al (2020)

Heliyon 7:e08093 Amornputti S, Ketsa S, van Doorn WG (2016) 1-methylcyclopropene (1-MCP) inhibits ethylene production of durian fruit which is correlated with a decrease in ACC oxidase activity in the peel

revealed that while transient skin-benefitting results were seen in 37.5% of patients with IV glutathione (1200 mg twice weekly for six weeks), 32% developed adverse events, again revealing a large risk-to-benefit ratio imbalance

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