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Animal studies using euglycemic clamp techniques, the gold standard for insulin sensitivity assessment, confirmed that chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity

At the same time, it is not very light and drying

Anecdotal reports from Phase 2 participants suggest that nausea severity is higher when dosing occurs in the early morning on an empty stomach, possibly because fasting amplifies the compound's gastric-slowing effect

Selenium is required by sheep and cattle for growth, and is needed to produce a number of enzymes that are important to normal function

It is highly addictive and withdrawal symptoms may be severe (but rarely fatal in adults)

When overdose patients are treated with NAC, this allows for a significant increase in glutathione activity