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In our cell-cycle analysis, the cells were seeded in 60-mm culture dishes and then serum-deprived for 24 h, after which the indicated treatment was administered

The 12 mg dose escalation group achieved a 2.02% reduction in HbA1c at 24 weeks, along with 16.94% body weight loss at 36 weeks

This signaling role means MOTS-c influences gene expression patterns related to metabolism, inflammation, and cellular stress responses throughout the body

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