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Conversely, rapid weight loss may also unmask pre-existing degenerative joint disease that was previously asymptomatic or less symptomatic

And the 12 mg group, which started at 2 mg and titrated up every four weeks, lost 24.2% of body weight

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Patients with genetic markers for faster GLP-1 receptor adaptation may benefit from earlier combination therapy (such as PlexusDx GLP-Squared, which combines semaglutide and tirzepatide) or periodic medication cycling to prevent plateau

It is primarily used to gently introduce the medication to the body without risking developing severe side effects