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The T allele of the + 369T/C SNP, which causes less TGF- release, was found to be more common in severe hypothyroidism compared to moderate hypothyroidism
Beyond NSA-involving metals in the LC flow path, we also believe that ionic interactions between positively charged sites on peptides or related impurities and residual siloxide groups on commonly used silica particles can exacerbate NSA, leading to sensitivity issues and poor peak shapes
Therapeutics E
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