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FIGURE 6 4 Discussion In this study, we reveal the beneficial effects of FOXO4-DRI on aortic vessels under various aging models

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Rather than acting solely as a cell-autonomous execution pathway, ferroptosis may, under permissive conditions, propagate across tissues through interconnected modes that include redox trigger waves, membrane-contact transfer, and extracellular paracrine signaling, collectively defining the multiscale architecture of ferroptotic contagion