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doi: 10.3389/fnut.2025.1541054 Received 06 December 2024 Accepted 20 March 2025 Published 09 April 2025 Volume 12 - 2025 Edited by Peng An, China Agricultural University, China Reviewed by Naseem Akhtar Qureshi, Al-Falah University, India Denis Fedorinov, Russian Medical Academy of Postgraduate Education, Russia Updates Copyright 2025 Overton, Emelyanova and Bunik

Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

Cell culture materials (DMEMF/12, neurobasal, phenol red-free neurobasal, B27, L-glutamine, antibiotic/antimycotic) were purchased from Life Technologies

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mTORC1 phosphorylates and activates p70S6K which in turn phosphorylates ribosomal protein S6 to enhance translation efficiency 23