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doi: 10.3390/biology11020159 21 Beltrn-GarcaJ.Osca-VerdegalR.PallardF
2013;8(5):e64751
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A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome
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Furthermore, epigenetic modulators like histone deacetylase inhibitors (HDACi) (e.g., vorinostat/SAHA, panobinostat, and entinostat) and Bromodomain and Extraterminal (BET) inhibitors may suppress HIF transcription, while RNA interference (RNAi), CRISPR-mediated gene editing, and antisense oligonucleotides offer gene-specific silencing of HIF isoforms or their co-activators
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