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The glucagon component appears to raise the bodys energy use and shift it toward burning stored fat, including liver fat, which is the leading explanation for the larger weight-loss numbers seen with retatrutide in trials

Tuesta et al., 2017)

Received for publication April 24, 2025

Most overdose cases resolve within 48 to 96 hours with IV fluids, antiemetic medications, and electrolyte correction in an emergency department or hospital setting

It accelerates degradation

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