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[Abstract]2018 Oct 1:117:42-50

Semaglutides effects extend to decreasing the risk of heart failure, heart attacks, and other major cardiovascular problems by also reducing the inflammation that can damage blood vessels

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Compared to the first-generation GLP-1R agonist, tirzepatide has three critical improvements: first, many residues in peptide backbone are changed to obtain GIPR-activating activity

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