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The assessment of ototoxicity is necessary for medications delivered via the otic route that are anticipated to affect the middle or inner ear during clinical application (Pasdelou et al

Clinically, the treatment strategies during phase I utilize conventional methods: patients should be treated with hypothermia, free radical scavengers (e.g., melatonin, erythropoietin, coenzyme Q10), excitatory amino acid receptor blocking agents, and/or neuroprotective agents

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