Melatonin mitigates ferroptosis and neuronal damage in ischemic stroke models, an effect achieved through the MDM2-mediated ubiquitination and degradation of ACSL4, leading to a reduction in ferroptosis markers like intracellular Fe 2+ (Yu, 2024
While branded versions like Ozempic, Wegovy, and Mounjaro can cost over \$1,000 per month, compounded semaglutide or tirzepatide can often be obtained for \$200\$600
adjust if necessary
Side effects are rare, generally mild, and may include occasional injection-site irritation, or mild nausea
Some studies suggest improvements in structural preservation and functional outcomes, though the mechanisms remain under investigation
these included 15 pharmacokinetic (PK) studies [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27], one pharmacodynamic (PD) study [28], one review with detailed PK data not elsewhere published [29], three conference abstracts [30,31,32], one case report [33] and one case series [34] (Fig