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The shuttle involves two different glycerol-3-phosphate dehydrogenases: one is cytosolic (GPD1), acting to produce glycerol-3-phosphate, and one is an integral protein (GPD2) of the inner mitochondrial membrane that acts to oxidize the glycerol-3-phosphate produced by the cytosolic enzyme

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Both short-acting and long-acting GLP-1 RAs have demonstrated beneficial effects by activating the AMPK-Sirt1 pathway, which has the potential to mitigate cardiac steatosis, oxidative stress, and apoptosis