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Experimental models of PD further corroborate BBB dysfunction
100 Dang B-TN, Duwa R, Lee S, Kwon TK, Chang J-H, Jeong J-H, Yook S
Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation

When administered through injections, it bypasses digestion and delivers faster, more effective results compared to oral supplements

DallIgna OP, Porcincula LO, Souza DO, Cunha RA, Lara DR (2003) Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity
S2CID 20438890.