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The STEP trials purposely excluded individuals with a history of major depressive disorder (MDD), bipolar disorder, schizophrenia, or other significant mental illnesses as well as participants with past suicide attempts or who had experienced clinically significant suicidal thoughts

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In general, GLP-1 may inhibit bone resorption via a calcitonin-dependent pathway, but this hypothesis still needs to be explored further

The multi-receptor approach of retatrutide demonstrates enhanced metabolic benefits across multiple pathways

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