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Fifty L of scintillation cocktail (OptiPhase SuperMix, PerkinElmer) were added and the plates were subsequently counted for radioactivity (counts per minute, CPM) in a MicroBeta 2 microplate counter (PerkinElmer)
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CHAC1 degrades GSH, reducing the GSH/GSSG ratio and impairing the activity of GPX4, an enzyme essential for detoxifying lipid peroxides
Code availability All scripts used for simulations in this research are publicly available (GitHub diederiklt/YeastHighTemperatures)
Last reviewed: June 28, 2026 Last updated: June 28, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
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