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The drugs effects became so intense that she claimed she was unable to keep down food or water, eventually leading to a hospital visit and a seizure caused by dehydration

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GLP-1 is actually produced not only in the bowel, thats whats mimicked by the medication, but its also in the brain

Methods: In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 30 or greater (27 in persons with 1 weight-related coexisting condition), who did not have diabetes, and randomly assigned them, in a 2:1 ratio, to 68 weeks of treatment with once-weekly subcutaneous semaglutide (at a dose of 2.4 mg) or placebo, plus lifestyle intervention

doi: 10.1016/j.ejps.2017.03.020

The medication's impact on gastric emptying means that food remains in the stomach longer, creating a prolonged feeling of fullness