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Sustained deficits in neuronal energy metabolism have been linked to the early stages of neurodegenerative processes, including the accumulation of beta-amyloid plaques and tau protein tangles, both hallmarks of Alzheimer's disease pathology [2]
doi: 10.2337/db15-0973 81 KanoskiSEFortinSMArnoldMGrillHJHayesMR
This was linked to improved bone mineral density in the tested animals [18]
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