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Redox Biol 57:102497
Anti-obesity and glucose-lowering pharmacotherapies predominantly exert their actions by inducing satiety (liraglutide, setmelanotide, lorcaserin, pramlintide, sibutramine) or by inducing malabsorption of nutrients (orlistat)
Metabolic Research Applications: At the cellular level, scientific experiments have demonstrated its value as a research tool for diabetes, metabolic syndrome, and lipodystrophy, enabling precise study of beta-3 adrenergic pathways
The effectiveness of tirzepatide for treating obesity is being evaluated in the SURMOUNT series of phase 3 RCTs, which, for the first time, demonstrated average weight reductions exceeding 20% with pharmacotherapy [23]
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