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Because safety hasn't been established, the standard advice is to skip it while pregnant or nursing unless a doctor says otherwise (WebMD)
Inhibition of cco-1 is a well-known intervention that, similarly to mrps-5 RNAi, activates the UPR mt and extends lifespan in worms 21
The study utilized male Sprague-Dawley rats as their source of tendon fibroblasts
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This may support the cells responsiveness to catecholamines, hormones promoting lipolysis
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